News

Promotion: Dr. Jie Luo Becomes Senior Research Scientist

Congratulations to Dr. Jie Luo, of the Ranish Lab, who has been promoted to senior research scientist. From Dr. Jeff Ranish:

Jie Luo is an extremely dedicated and talented scientist. When he joined ISB in 2006 as a postdoctoral fellow, he had no experience in mass spectrometry-based proteomics. Now he is a leader in the field of structural and functional proteomics. He has conceptualized and implemented several innovative proteomics strategies for studying protein-protein interactions (PPIs) in macromolecular assemblies, and he is currently developing technology to study PPIs on a large scale.  Jie is also quite interactive, collaborating with researchers throughout the world to study the architecture of macromolecular assemblies. A good example of his work can be seen in his recent paper on the architecture of the general transcription and DNA repair factor TFIIH (Luo, et al., Molecular Cell, 2015).

Jie excels at pushing the boundaries of system biology research, and he does it while maintaining a positive attitude. Jie is valuable asset to ISB and it is a pleasure to work with him.

Recent Articles

  • A new crosslinking mass spectrometry technology for studying conformational and structural changes in protein complexes

    Our work describing a new crosslinking mass spectrometry technology for studying conformational and structural changes in proteins and proteins complexes has been published in eLife.

  • A Better Understanding of DNA Unpacking

    Jie Luo and Jeff Ranish collaborated on a project to determine the molecular architecture of the NuA4/Tip60 co-activator complex. This protein complex functions to allow proper control of gene expression and DNA repair by allowing other proteins to access the DNA in the cell nucleus. The new information about the structure and function of TIP60 could provide insight into different diseases where the protein complex plays a role, such as Alzheimer’s and various cancers. The work was published in Science.

  • Ranish lab published a preprint describing a new crosslinking mass spectrometry technology

    Dynamic conformational and structural changes in proteins and protein complexes play a central and ubiquitous role in the regulation of protein function, yet it is very challenging to study these changes, especially for large protein complexes, under physiological conditions. To address this challenge, we created a novel isobaric crosslinker, Qlinker, for studying conformational and structural changes in proteins and protein complexes using quantitative crosslinking mass spectrometry (qCLMS).