Dr. Jeff Ranish and Dr. Mark Gillespie

Mysteries of Cell Fate Unlocked with New Measurement and Modeling Techniques 

In the cellular process of differentiation, information about the concentrations of an important class of proteins residing in a cell’s nucleus has been lacking, a missing link needed for scientists to fully understand how the process works. ISB researchers have quantified this important class of proteins that play a key role in the formation of red blood cells.

Researchers Find Key Protein Tied to Production of ‘Good’ Cholesterol

3 Bullets: Inflammation causes cholesterol buildup and leads to cardiovascular disease, the leading cause of death in the world ISB, Seattle Biomed, and Oregon State University researchers collaborate to identify a compendium of proteins that control expression of a key regulator of cholesterol efflux Targeting cholesterol efflux to HDL is a potentially important therapeutic strategy for preventing and treating cardiovascular disease By Dr. Mark Gillespie Cells of the immune system,…

New Structural Map Helps To Understand Aggressive Tumors

3 Bullets: Aggressive tumor growth is linked to high activity of a macromolecular assembly called RNA polymerase I. ISB and FHCRC researchers collaborate to map the architecture of the assembly using a powerful crosslinking-mass spectrometry (CXMS) technology. Structural maps provide important insights into therapeutic targets for cancer treatment. By Mark Gillespie Rapidly growing tumor cells require large amounts of protein for their survival. This increased protein synthesis, or translation, can…

Dr. Jeff Ranish Receives Promotion

Congratulations to Dr. Jeff Ranish on his promotion to Associate Professor. Jeff has been with ISB since its founding in 2000. Read about the Ranish lab group.