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Mysteries of Cell Fate Unlocked with New Measurement and Modeling Techniques

Posted on April 23, 2020

In the cellular process of differentiation, information about the concentrations of an important class of proteins residing in a cell’s nucleus has been lacking, a missing link needed for scientists to fully understand how the process works. ISB researchers have quantified this important class of proteins that play a key role in the formation of red blood cells.

ISB’s Innovator Award Program rewards high-risk, cross-disciplinary research projects

Posted on June 29, 2018

The Innovator Award Program at Institute for Systems Biology is an annual internal initiative started in 2017 that aims to stimulate creativity, innovation and collaboration within ISB, to provide funding support for high-risk, high-reward projects, and to develop new technologies and discoveries that will impact the entire research organization.

Dr. Jeff Ranish Promoted to Professor

Posted on June 29, 2017

We are pleased to announce the promotion of Jeff Ranish to Professor. Jeff has been a pioneer in the fields of mass spectrometry and gene regulation. His impressive history of innovation in mass spectrometry technology has produced novel protein-crosslinking approaches to identify large scale protein-protein interactions in complex mixtures. He has applied the innovations to important biological problems, resulting in notable findings such as the characterization of multiple topological and…

Promotion: Dr. Jie Luo Becomes Senior Research Scientist

Posted on April 25, 2016

Congratulations to Dr. Jie Luo, of the Ranish Lab, who has been promoted to senior research scientist. From Dr. Jeff Ranish: Jie Luo is an extremely dedicated and talented scientist. When he joined ISB in 2006 as a postdoctoral fellow, he had no experience in mass spectrometry-based proteomics. Now he is a leader in the field of structural and functional proteomics. He has conceptualized and implemented several innovative proteomics strategies…

Researchers determine architecture of a macromolecular complex regulating gene expression and DNA repair

Posted on September 8, 2015

General transcription factor TFIIH plays central roles in gene transcription and DNA repair ISB researchers and collaborators map the architecture of the TFIIH complex using powerful crosslinking-mass spectrometry (CXMS) technology and integrative modeling Structural maps provide critical insights into how mutations in TFIIH subunits lead to disease phenotypes By Jie Luo and Mark Gillespie The expression, or transcription, of genes controls the identity and function of a cell. DNA damage…

Researchers Find Key Protein Tied to Production of ‘Good’ Cholesterol

Posted on March 9, 2015

3 Bullets: Inflammation causes cholesterol buildup and leads to cardiovascular disease, the leading cause of death in the world ISB, Seattle Biomed, and Oregon State University researchers collaborate to identify a compendium of proteins that control expression of a key regulator of cholesterol efflux Targeting cholesterol efflux to HDL is a potentially important therapeutic strategy for preventing and treating cardiovascular disease By Dr. Mark Gillespie Cells of the immune system,…

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